Endocrine Abstracts

The hormone assessment in saliva is emerging as a new valuable tool for clinical and research purposes. Salivary levels are supposed to reflect the free fraction of circulating steroids, thus representing a more informative indicator of their activity. Moreover, saliva collection is not stressful and does not require medical assistance, allowing reliable and multiple sampling in a day. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) technology offers high s...

Steroid profiling by liquid chromatography–tandem mass spectrometry (LC–MS/MS) offers an accurate and simultaneous detection of a panel of steroids with several advantages over traditional assays. However, only a few studies have investigated the steroid profiling in sporadic adrenocortical adenomas. Our aim was therefore to investigate steroid secretion by LC–MS/MS in patients with non-secreting adrenocortical adenomas (NSA) and subclinical hypercortisolism (SH...

Introduction: The relationship between food intake and hypothalamic–pituitary–adrenal (HPA) axis has been studied in the development of visceral adiposity and obesity. The HPA axis may interact with the reward system, thus influencing food choices. On the other hand, it has been shown that macronutrients differently modulate the HPA axis activity.The aim of this study was to evaluate the dietary habits in subjects with adrenal masses (adenoma o...

The endocannabinoid system (ECS) is involved in the regulation of food intake and energy expenditure. Increased level of EC lipid mediators anandamide (AEA) and 2-arachydonoylglycerol (2AG) and/or a higher expression of cannabinoid receptor type 1 in central and peripheral districts are supposed to contribute to the development and maintenance of obesity and related dismetabolism. To understand the ECS response to insulin signal and to anthropometric and biochemical parameters...

Background: Chronic glucocorticoids excess leads to morphological and functional cardiac alterations, a substrate for arrhythmias. Autonomous cortisol secretion (ACS) from adrenal incidentalomas is a model of chronic endogenous hypercortisolism, leading to severe cardiovascular diseases.Aim: To investigate prevalence and incidence of atrial fibrillation in a large cohort of patients with adrenal incidentalomas and ACS.Methods: Afte...